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UT-GPCR005 Fluorescence anisotropy time-series of competition binding between unlabeled ligands of M1 muscarinic acetylcholine receptor and TAMRA labeled UR-MK342

dc.contributor.authorLaasfeld, Tõnis
dc.contributor.authorBláhovcová, Hana
dc.contributor.authorHollo, Kaspar
dc.contributor.authorRinken, Ago
dc.contributor.authorVeiksina, Santa
dc.coverage.spatialTartu, Estoniaen
dc.date.accessioned2026-04-02T07:43:03Z
dc.date.available2026-04-02T07:43:03Z
dc.date.issued2026-03-26
dc.identifier.urihttps://datadoi.ee/handle/33/738
dc.identifier.urihttps://doi.org/10.23673/re-572
dc.description.abstractFluorescence anisotropy time-series of competition ligand binding between unlabeled competitors of M1 muscarinic acetylcholine receptor and TAMRA labeled UR-MK342. The dataset contains kinetic traces of UR-MK259, UR-SK-75, McN-A-343, UR-SK-59, Scopolamine, Telenzepine, 4-DAMP, Carbachol, Pilocarpine, Clozapine, Pirenzepine, Atropine, Acetylcholine, Trospium, NMS, Arecoline, W84, Xanomeline and LY2119620 in competition with TAMRA labeled muscarinic acetylcholine recepotor fluorescent ligand UR-MK342. The dataset also contains non-linear regression fits of these time-series. Details of experimental setup are given in the related publication.en
dc.format.pzfxen
dc.format.xlsxen
dc.language.isoenen
dc.publisherUniversity of Tartuen
dc.relationPSG912en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAllosteric modulatoren
dc.subjectBitopic liganden
dc.subjectFluorescence polarizationen
dc.subjectG protein-coupled receptoren
dc.subjectKinetic analysisen
dc.subjectLY2119620en
dc.titleUT-GPCR005 Fluorescence anisotropy time-series of competition binding between unlabeled ligands of M1 muscarinic acetylcholine receptor and TAMRA labeled UR-MK342en
dc.typeinfo:eu-repo/semantics/dataseten
dc.relation.iscitedby10.1016/j.bcp.2026.117911en
dc.relation.iscitedbyLaasfeld T, Bláhovcová H, Hollo K, Veiksina S, Rinken A, Allikalt A. Kinetic assays to characterize fluorescent ligand binding to muscarinic acetylcholine M1 receptor. Biochem Pharmacol. 2026 Mar 20:117911. doi: 10.1016/j.bcp.2026.117911. Epub ahead of print. PMID: 41865899.en


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