2026-05-22T01:13:02Zhttps://datadoi.ee/oai/requestoai:datadoi.ee:33/7382026-04-06T06:37:11Zcom_33_391com_33_3col_33_392
UT-GPCR005 Fluorescence anisotropy time-series of competition binding between unlabeled ligands of M1 muscarinic acetylcholine receptor and TAMRA labeled UR-MK342
Laasfeld, Tõnis
Bláhovcová, Hana
Hollo, Kaspar
Rinken, Ago
Veiksina, Santa
Anni Allikalt
Allosteric modulator
Bitopic ligand
Fluorescence polarization
G protein-coupled receptor
Kinetic analysis
LY2119620
Fluorescence anisotropy time-series of competition ligand binding between unlabeled competitors of M1 muscarinic acetylcholine receptor and TAMRA labeled UR-MK342. The dataset contains kinetic traces of UR-MK259, UR-SK-75, McN-A-343, UR-SK-59, Scopolamine, Telenzepine, 4-DAMP, Carbachol, Pilocarpine, Clozapine, Pirenzepine, Atropine, Acetylcholine, Trospium, NMS, Arecoline, W84, Xanomeline and LY2119620 in competition with TAMRA labeled muscarinic acetylcholine recepotor fluorescent ligand UR-MK342. The dataset also contains non-linear regression fits of these time-series. Details of experimental setup are given in the related publication.
2026-04-02T07:43:03Z
2026-04-02T07:43:03Z
2026-03-26
info:eu-repo/semantics/dataset
https://datadoi.ee/handle/33/738
https://doi.org/10.23673/re-572
en
PSG912
10.1016/j.bcp.2026.117911
Laasfeld T, Bláhovcová H, Hollo K, Veiksina S, Rinken A, Allikalt A. Kinetic assays to characterize fluorescent ligand binding to muscarinic acetylcholine M1 receptor. Biochem Pharmacol. 2026 Mar 20:117911. doi: 10.1016/j.bcp.2026.117911. Epub ahead of print. PMID: 41865899.
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
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Tartu, Estonia
University of Tartu