Kliinilise meditsiini andmed

Exploratory Analysis of Epilepsy Biomarkers Using Untargeted Metabolomics Across Multiple Cohorts

Oja, Kaisa Teele — 2025-01-01T00:00:00Z

Exploratory Analysis of Epilepsy Biomarkers Using Untargeted Metabolomics Across Multiple Cohorts Oja, Kaisa Teele; Ilisson, Mihkel; Reinson, Karit; Muru, Kai; Reimand, Tiia; Kennedy, Adam D.; Sommerville, Laura; Michelotti, Gregory; Pajusalu, Sander; Õunap, Katrin This dataset contains the metabolomics and lipidomics data of 110 pediatric samples. It was collected for use in a paper together with data from two Estonian Biobank cohorts (access is described here: https://genomics.ut.ee/en/content/estonian-biobank). The pediatric cohort data is being made public both to act as supplementary data for the publication and in order for other researchers to use this data in their own work.

10 months 4000IU vitamin D supplementation decreases the risk of vitamin D deficiency but has no effect to physical performance during active military training in high-latitudes – a randomized controlled trial

Rips, Leho — 2022-12-01T00:00:00Z

10 months 4000IU vitamin D supplementation decreases the risk of vitamin D deficiency but has no effect to physical performance during active military training in high-latitudes – a randomized controlled trial Rips, Leho; Varblane, Ahti; Kull, Mart; Rahu, Madis; Kartus, Jüri-Toomas; Gapeyeva, Helena; Mölder, Hanno; Kibur, Ragnar; Laidvere, Marika; Toom, Alar Background: Vitamin D deficiency with related consequences to human health has growing interest to military specific researchers worldwide. Many specific conditions could put soldiers in to the higher risk of vitamin D deficiency. Under high level of physical pressure during military training might increase the need of vitamin D in human body and therefore supplementation with vitamin D could be crucial for general health and physical fitness. Study Design: Longitudinal, triple-blinded, randomized, controlled trial. Methods: 113 men conscripts from the Estonian Army were randomized into two vitamin D supplementation groups: 58 to an 4000 IU and 58 to an 600 IU group. The length of the follow-up was ten months, from July 2021 until May 2022. Physical fitness and hand grip tests were performed 3 times and blood serum (25(OH)D), parathyroid hormone, calcium, ionized calcium values were measured 4 times during the study period. Results: The 600IU group had a significantly lower mean value of 25(OH)D in all time points during the study compared to 4000IU group (p<0.001) except baseline. Non of the study subjects in the Group A 600IU reached sufficient level of 25(OH)D in January and May. 61.3% in the 600IU and 30.6% 4000IU group had 25(OH)D levels under 50 nmol/L in May. No statistically significant differences found in the body weight and vitamin D correlation analysis in any time point on between study groups. No statistically significant differences in PTH, i-Ca were found between study groups at any time point except Ca results. No significant differences at any time points were revealed in the physical fitness test and hand grip strength tests except in non-dominant hand grip test in October. Conclusion: Ten months vitamin D3 4000IU supplementation decreased risk of vitamin D deficiency but had no effect to physical fitness compared to low dosage vitamin D supplementation. Trial registration: ClinicalTrials.gov Identifier: NCT04939636. Prospectively registered 13 October 2020. Embargoed til published

Men have higher risk of kinesiophobia after anterior cruciate ligament reconstruction in long term follow up.

Rips, Leho — 2022-01-01T00:00:00Z

Men have higher risk of kinesiophobia after anterior cruciate ligament reconstruction in long term follow up. Rips, Leho; Luik, Mihkel; Koovit, Tauno; Saar, Helena; Kuik, Rein; Kartus, Jüri-Toomas; Rahu, Madis Background Psychological and physiological factors could negatively affect patients' recovery and increase re-injury rate after anterior cruciate ligament reconstruction (ACLR). In daily practice surgeons and physiotherapists see athletes struggling to improve muscle strength and complaining of lack of self-confidence during the progress of return to sport. The Tampa Scale for Kinesiophobia is a valid questionnaire to measure a patient's psychological status and isokinetic test is widely used to measure muscle recovery. Hypothesis Patients with kinesiophobia have inferior self reported and functional outcomes after ACLR. Methods 140 patients, 100 (71%) men and 40 (29%) women, mean age 32.5 (±8.3), were included in the study 5.5 (±1.25) years after ACLR. All patients were operated by two senior surgeons. Preoperative and postoperative assessments were performed by two sports specialized physical therapists. Patients completed the Knee injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee score and Tampa Scale of Kinesiophobia (TSK-17). Quadriceps and hamstring muscle isokinetic strength was assessed at 60°/sec and 180°/sec using the HumacNorm dynamometer. Functional performance was tested with the single-leg-hop test for distance and the Y-balance test for anterior reach. Variables of the study were described by means and standard deviations. Shapiro-Wilk test was conducted to test for normality of the variables and unpaired t-tests were used to test for differences between subgroups. After tests were conducted, simple Bonferroni adjustment was applied to account for the number of tests made. Results 68/140 patients (48.6%) reported a Tampa kinesiophobia score equal or higher than 37 points, above which is the cut off score for kinesiophobia. Patients with kinesiophobia had statistically significant lower scores in the KOOS Symptoms (p=0.001) and Quality of Life subscores (p=0.001), Total score (p=0.001) and the Oxford Knee Score (p=0.024). Isokinetic peak torque muscle strength mean deficits at 60°/sec and 180°/sec for knee flexion and extension were between 6% and 7% for patients with kinesiophobia and between 2% to 4% for patients without kinesiophobia compared with the contralateral side, with no significant differences between groups. There was no statistically significant difference in the Single-leg-hop test for distance leg ratio (0.98 (±0.19) and 1.00 (±0.26)) and the Y-balance test for anterior reach leg ratio (0.99 (±0.08) and 1.01 (±0.07)) respectively between the groups. Conclusion At 5 years after ACLR operated leg functional performance is equal to nonoperated leg. However kinesiophobia is present in nearly half of patients. Strength and functional tests alone are not good enough instruments for assessing complete recovery, on the other hand self-reported questionnaires have high correlation to kinesiophobia after ALCR. Further studies are needed to avoid development of kinesiophobia as well how to recognize phobia at early stages of rehabilitation. Embargoed until October 2024

Arterial structure in 18-year-old males is dependent on physical activity at 12-years and cumulative cardiorespiratory fitness from puberty to late adolescence - Supplemental Appendix

Kraav, Juta — 2022-01-01T00:00:00Z

Arterial structure in 18-year-old males is dependent on physical activity at 12-years and cumulative cardiorespiratory fitness from puberty to late adolescence - Supplemental Appendix Kraav, Juta; Tillmann, Vallo; Jürimäe, Jaak; Mäestu, Evelin; Tamme, Reeli; Remmel, Liina; Zagura, Maksim Supplemental Appendix for the article "Arterial structure in 18-year-old males is dependent on physical activity at 12-years and cumulative cardiorespiratory fitness from puberty to late adolescence.", published in Pediatric Excercise Science.